Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

Literature Life Science

For this study HTRF IP-one accumulation assay was used to determine Gi protein activation


Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk. Although the strongest association signal was highly significant (P


Nat Genet. 2012 ;44(3):297-301.

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